Background: Assessment of symptoms should be the primary outcome measure in dyspepsia clinical trials. This requires a reliable, valid and responsive questionnaire that measures the frequency and severity of dyspepsia. The Leeds Dyspepsia Questionnaire fulfils these characteristics, but is long and was not designed for self-completion, so a shorter questionnaire was developed the Short-Form Leeds Dyspepsia Questionnaire. Aim: To assess the acceptability, interpretability, internal consistency, reliability, validity and responsiveness of the Short-Form Leeds Dyspepsia Questionnaire in primary and secondary care.

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Background: There is currently no validated questionnaire that assesses both the presence and severity of dyspepsia. Aim: To develop the Leeds Dyspepsia Questionnaire LDQ as a measure of the presence and severity of dyspepsia, and to assess the validity, reliability and responsiveness of this instrument.

Methods: Unselected patients attending either a hospital dyspepsia clinic or a general practice surgery were interviewed by a trained gastroenterologist or a general practitioner on the presence and severity of dyspepsia. This opinion was compared with the results of the nurse-administered LDQ.

Test-retest reliability was assessed by the same research nurse re-administering the LDQ days after the initial visit in a subgroup of hospital patients. In a further subgroup of patients one researcher interviewed the patients and a second researcher re-administered the LDQ within 30 min to evaluate inter-rater reliability.

The responsiveness of the LDQ was measured by repeating it in patients with endoscopically proven peptic ulcer or oesophagitis 1 month after receiving appropriate therapy. Results: The LDQ was administered to 99 general practice and hospital patients.

The weighted kappa statistic for the agreement between the LDQ and the clinician for the severity of dyspepsia was 0. The kappa statistic for test-retest reliability was 0. The LDQ had excellent inter-rater reliability with a kappa statistic of 0. The median LDQ score fell from Conclusion: The LDQ is a valid, reliable and responsive instrument for measuring the presence and severity of dyspepsia.

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Gatta L, et al. Intern Emerg Med. Epub Oct 1. PMID: Nkurunziza A, et al. BMJ Open. Mandarin version of the Leeds Dyspepsia Questionnaire: A valid instrument for assessing symptoms in Asians. Leow HR, et al. J Dig Dis. Symptom-based outcome measures for dyspepsia and GERD trials: a systematic review.

Fraser A, et al. Am J Gastroenterol. PMID: Review. Barenys M, et al. Med Clin Barc. Show more similar articles See all similar articles. Cited by 37 articles Gastrointestinal dysfunction in Parkinson's disease. Lubomski M, et al. J Neurol. Epub Jan Park MS, et al. PLoS One. Clinical Trial. Prevalence of Helicobacter pylori infection in sexual partners of H. Sgambato D, et al. United European Gastroenterol J. Epub Sep 6. Majeed M, et al. J Med Food. Epub Aug Khalid MA, et al.

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The Short-Form Leeds Dyspepsia Questionnaire Validation Study



Leeds Dyspepsia Questionnaire (LDQ)


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