GENOTOXICIDADE AMBIENTAL PDF

Use of genotoxicity biomarkers and gene expression on the evaluation of gas station attendants exposed to gasoline fumes. Rio de Janeiro, RJ, Brasil. Belo Horizonte, MG, Brasil. On environmental and occupational health fields, genotoxicity biomarkers have been widely used for this evaluation. This can be explained by the small number of countries where such job still exists and by the limitations for developing research in such countries.

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Use of genotoxicity biomarkers and gene expression on the evaluation of gas station attendants exposed to gasoline fumes. Rio de Janeiro, RJ, Brasil. Belo Horizonte, MG, Brasil. On environmental and occupational health fields, genotoxicity biomarkers have been widely used for this evaluation. This can be explained by the small number of countries where such job still exists and by the limitations for developing research in such countries.

Posteriormente, Singh et al. Fonte: imagens elaboradas pelos autores deste artigo. Speit et al. Rekhadevi et al. A pesquisa de Moro et al.

Fonte: Elaborada pelos autores. Em , Bukvic et al. Trata-se de uma metodologia bem estabelecida e validada 22 , 23 , 59 - Carere et al.

Bollati et al. Smith et al. Oh et al. Amorim LCA. Rev Bras Med Trab. Fundamentos de Toxicologia. World Health Organization. Collins AR, Azqueta A. DNA repair as a biomarker in human biomonitoring studies; further applications of the comet assay.

Mutat Res. Biomonitoring Equivalents for benzene. Regul Toxicol Pharmacol. Genotoxicity and oxidative stress in gasoline station attendants. Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ C.

Nucleic Acids Res. Jablonka E, Lamb MJ. International Agency for Research on Cancer. Some Industrial Chemicals and DyeStuffs. Risk Chem. Lyon, France; American Conference of Governmental Industrial Hygienists. Cincinnati: OH; Environmental Health Criteria Biomarkers and Risk Assessment concept and Principles. ICPS: Geneva; Barale R. Il benzene: tossicologia, ambienti di vita e di lavoro. The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Crit Rev Toxicol. Toxicol Lett. Buschinelli JT. Biomarkers in risk assessment: Validity and validation. EHC Genetic effects of petroleum fuels: II. Analysis of chromosome loss and hyperploidy in peripheral lymphocytes of gasoline station attendants.

Environ Mol Mutagen. Low air levels of benzene: correlation between biomarkers of exposure and genotoxic effects.

Genotoxicity in filling station attendants exposed to petroleum hydrocarbons. Ann Occup Hyg. Environ Monit Assess. Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene. A simple technique for quantitation of low levels of DNA damage in individual cell. Exp Cell Res.

Enhancing the sensitivity of the comet assay as a genotoxocity test, by combining it with bacterial repair enzyme. The comet assay: what can it really tell us? Oliver PL. DNA damage and repair in individual cells: applications of the comet assay in radiobiology.

Int J Radiat Biol. The influence of temperature during alkaline treatment and electrophoresis on results obtained with the comet assay. New application of the comet assay: Chromosome-Comet Assay. J Histochem Cytochem. Azqueta A, Collins AR. The essential comet assay: a comprehensive guide to measuring DNA damage and repair. Arch Toxicol. Detection of DNA damage in human lymphocytes by alkaline single cell gel electrophoresis after exposure to benzene or benzene metabolites.

DNA oxidation: Investigating its key role in environmental mutagenesis with the comet assay. Lipid peroxidation and its role in atherosclerosis. Br Med Bull. Lyons TJ. Glycation and oxidation: a role in the pathogenesis of atherosclerosis.

Am J Cardiol. Vinson JA. Oxidative stress in cataracts. Pathophysiol ; 13 3 Grollman AP, Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. Collins AR. Investigating oxidative DNA damage and its repair using the comet assay. Decreased glutathione content and glutathione S-transferase activity in red blood cells of coal miners with early stages of pneumoconiosis.

Br J Ind Med. Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models.

Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc. Mueller WU, Rode A. The micronucleus assay in human lymphocytes after high radiation doses Gy. International Atomic Energy Agency. Viena: Organisation for Economic Co-operation and Development. OECD Publishing; An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

Relation of increased chromosomal damage to future adverse cardiac events in patients with known coronary artery disease.

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Semina: Ciências Biológicas e da Saúde

The use of Allium cepa test as a bioindicator of genotoxicity of medicinal plants infusions. Unitermos: Allium cepa, plantas medicinais, citotoxicidade, mutagenicidade. All over the world, many species of medicinal plants are used for disease treatments. However, most of them were not deeply studied; and the presence of cytotoxic or mutagenic substances in their composition or resulting from their metabolism may be harmful to human beings. The mutagenic effects caused by such substances result in chromosomal changes which are detecTable during the cell cycle of a species through cytogenetic analysis.

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Abstract The interest in environmental genotoxicity studies has increased, and the micronucleus test MN is one of the most popular and promising tests on ecotoxicology, representing a cytogenetic indicator of DNA damage in dividing cells. Genotoxicity studies employed this methodology to evaluate possible genotoxic risk due to exposition to hazardous xenobiotics in different organisms, including aquatic sentinel organisms. In this context, bivalve mollusks stand out because of some aspects of their way of life, such as filtering food from the water. In bivalves, the MN test evaluates aneugenic and clastogenic effects preferably in hemocytes and gill cells. In the last two decades an interesting increase can be observed in the number of studies using the MN test in bivalve species, both in biomonitoring in situ and in the genotoxicity assays under controlled laboratory conditions, which are targeted to several chemicals with genotoxic and carcinogenic potential in the aquatic environment. Analysis of micronuclei in blue mussels and fish from the Baltic and the North Seas.

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