ANTAGONISTAS Y ANTIDOTOS PDF

Baracat II. I Doutor. Xarope de ipeca. O volume de retorno deve ser o mesmo do instilado 14, Am J Emerg Med.

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Structural and functional characterization of a specific antidote for ticagrelor. Blood ; 22 : , May Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome patients. However, antiplatelet therapy can be associated with an increased risk of bleeding.

Here, we present data on the identification and the in vitro and in vivo pharmacology of an antigen -binding fragment Fab antidote for ticagrelor. The Fab has a 20 pM affinity for ticagrelor , which is times stronger than ticagrelor 's affinity for its target, P2Y Despite ticagrelor 's structural similarities to adenosine , the Fab is highly specific and does not bind to adenosine , adenosine triphosphate , adenosine 5'-diphosphate, or structurally related drugs. The antidote concentration-dependently neutralized the free fraction of ticagrelor and reversed its antiplatelet activity both in vitro in human platelet-rich plasma and in vivo in mice.

Lastly, the antidote proved effective in normalizing ticagrelor -dependent bleeding in a mouse model of acute surgery. This specific antidote for ticagrelor may prove valuable as an agent for patients who require emergency procedures.

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