Treatment can be a single or repeated sleep deprivation, total all night or partial second half of the night. Relapse can be prevented by daily light therapy, concomitant administration of SSRIs, lithium for bipolar patients , or a short phase advance of sleep over 3 days following a single night of wake therapy. Combinations of these interventions show great promise. As an adjuvant to conventional antidepressants in unipolar patients, or lithium in bipolar patients, morning light hastens and potentiates the antidepressant response.
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Treatment can be a single or repeated sleep deprivation, total all night or partial second half of the night. Relapse can be prevented by daily light therapy, concomitant administration of SSRIs, lithium for bipolar patients , or a short phase advance of sleep over 3 days following a single night of wake therapy.
Combinations of these interventions show great promise. As an adjuvant to conventional antidepressants in unipolar patients, or lithium in bipolar patients, morning light hastens and potentiates the antidepressant response.
Light therapy shows benefit even for patients with chronic depression of 2 years or more, outperforming their weak response to drugs. This method provides a viable alternative for patients who refuse, resist or cannot tolerate medication, or for whom drugs may be contraindicated, as in antepartum depression.
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Cite Favorites. Martiny K. Dan Med J. PMID: Review. Chronobiological therapy for mood disorders. Dallaspezia S, Benedetti F. Dallaspezia S, et al. Expert Rev Neurother. Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy chronotherapeutics in drug-resistant bipolar depression.
Benedetti F, et al. J Clin Psychiatry. PMID: Morning light therapy for juvenile depression and severe mood dysregulation: study protocol for a randomized controlled trial. Bogen S, et al. Clinical Trial. Praschak-Rieder N, et al. Wien Med Wochenschr. Show more similar articles See all similar articles.
Formentin C, et al. Front Physiol. The human hypothalamus in mood disorders: The HPA axis in the center. Bao AM, et al. IBRO Rep. Early versus late wake therapy improves mood more in antepartum versus postpartum depression by differentially altering melatonin-sleep timing disturbances. Parry BL, et al. J Affect Disord. Epub Nov 5. Karthikeyan R, et al. J Circadian Rhythms.
Osborne LM. Obstet Gynecol Clin North Am. Show more "Cited by" articles See all "Cited by" articles. Publication types Editorial Actions.
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It is recognized as the treatment of choice for seasonal affective disorder and has been successfully used in nonseasonal depression and other psychiatric or neurologic illnesses, including bulimia nervosa and Alzheimer's disease. At the same time, 'wake therapy' is the fastest antidepressant known. Chronotherapeutic combinations of light and wake therapy achieve fast results and, by reducing residual symptoms, also minimise relapse. This manual introduces chronotherapeutics for depression, a new synthesis of non-pharmacologic interventions designed to accelerate remission in bipolar and unipolar patients alike. It examines the underlying clinical research, explains the involvement of the circadian timing system, and provides hands-on instructions for treating inpatients and outpatients.
Chronotherapeutics for affective disorders: A clinician's manual for light and wake therapy
Chronotherapeutics (Light and Wake Therapy) in Affective Disorders