Rheumatoid arthritis RA is a chronic autoimmune multisystemic inflammatory disease which affects many organs but predominantly attacks the synovial tissues and joints. Onset is generally in adulthood, peaking in the 4 th and 5 th decades. The pediatric condition, juvenile rheumatoid arthritis , is discussed separately. Onset may be insidious or abrupt.
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Rheumatoid arthritis RA is a chronic autoimmune multisystemic inflammatory disease which affects many organs but predominantly attacks the synovial tissues and joints. Onset is generally in adulthood, peaking in the 4 th and 5 th decades. The pediatric condition, juvenile rheumatoid arthritis , is discussed separately. Onset may be insidious or abrupt. Early features commonly include tiredness, malaise, and generalized aches.
Arthritis symptoms typically first develop in the hands and wrists in a symmetric, proximal distribution. Feet and large joints may also be involved. Etiology is unknown but is probably multifactorial. Activation and accumulation of T CD4 cells in the synovium start a cascade of inflammatory responses which result in:. The inflammatory response leads to pannus formation. Pannus is an edematous thickened hyperplastic synovium infiltrated by lymphocytes T and B, plasmocytes, macrophages and osteoclasts.
Pannus will gradually erode bare areas initially, followed by the articular cartilage. It causes fibrous ankylosis which eventually ossifies 2,3. Diagnosis is based on a combination of clinical, radiographic, and serological criteria. Non-musculoskeletal features of rheumatoid arthritis tend to occur late in the disease and include:. For further details, please refer to musculoskeletal manifestations of rheumatoid arthritis.
S plenomegaly may be seen as part of Felty syndrome , usually in long standing rheumatoid arthritis. Treatment of rheumatoid arthritis is aimed at improving the symptoms and slowing disease progression. The disease carries a significant burden of disability.
There is also a reduction in life expectancy, with excess mortality usually related to its non-articular manifestations 5,6. Rheumatoid arthritis was a term first coined by British physician Sir Alfred Baring Garrod in Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Updating… Please wait.
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On this page:. Quiz questions. Gabriel SE. The epidemiology of rheumatoid arthritis. North Am. Edit article Share article View revision history Report problem with Article. URL of Article. Article information.
Systems: Musculoskeletal , Chest , Cardiac. Tag: arthritis. Support Radiopaedia and see fewer ads. Cases and figures. Figure 1: distribution in the hand Figure 1: distribution in the hand.
Case 1: rheumatoid hands Case 1: rheumatoid hands. Case 2: dens involvement Case 2: dens involvement. Case 3: rheumatoid lung Case 3: rheumatoid lung. Case 4: cervical spine involvement Case 4: cervical spine involvement. Case 5 Case 5. Case 6 Case 6. Case 7: wrist Case 7: wrist. Case 8: forefoot Case 8: forefoot. Case 8: knee Case 8: knee. Case elbow Case elbow. Case hands Case hands. Loading more images Close Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys.
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Translation of "Artrite" in English
Translate texts with the world's best machine translation technology, developed by the creators of Linguee. Look up words and phrases in comprehensive, reliable bilingual dictionaries and search through billions of online translations. Look up in Linguee Suggest as a translation of "artrite gotosa" Copy. DeepL Translator Linguee. Open menu. Translator Translate texts with the world's best machine translation technology, developed by the creators of Linguee. Linguee Look up words and phrases in comprehensive, reliable bilingual dictionaries and search through billions of online translations.
Use of systemic corticosteroids in the treatment of acute gouty arthritis : what is the evidence? Rev Port Med Geral Fam [online]. ISSN Aim: To evaluate the efficacy and safety of systemic corticosteroids SC in the treatment of acute gouty arthritis AGA and its benefits to classic treatment namely colchicine and nonsteroidal anti-inflammatory drugs NSAIDs. Review methods: Clinical guidelines NOC , systematic reviews RS , randomized controlled trials RCT and meta-analyses MA , published between June and June , using the MeSH terms glucocorticoids, gout suppressants, adrenal cortex hormones, acute disease, gout, and hyperuricemia. If on the one hand, some studies mention a more significant improvement of the symptoms with the use of SC, especially in the first days of treatment, on the other hand, they mention them as effective as the classic treatment. Thus, the choice of agent for AGA treatment should be determined based on the patient's profile.
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