Aim of the study: Achyrocline satureioides Lam. Its infusion is widely utilized for the treatment of several digestive ailments, as an anti-inflammatory preparation, as a sedative and anti-atherosclerotic. Circumstantial evidence suggests that extracts of Achyrocline satureioides may have immunomodulatory properties. The present study was therefore devised to investigate the in vitro effects Achyrocline satureioides infusion on human peripheral blood mononuclear cells PBMCs and polymorphonuclear leukocytes PMNs. Materials and methods: Experiments were performed on cells isolated from venous blood obtained from healthy donors. Lower concentrations of the infusion 0.

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Achyrocline satureioides Lam. Different extracts of inflorescences have been tested for anti-inflammatory, analgesic, antispasmodic, constipating and sedative activities. The aqueous extracts maceration and decoction and ethanolic macerate exhibited an inhibition of the carrageenan-induced rat paw oedema at a dose range of mg kg-1 i.

The gastrointestinal propulsion of a charcoal suspension was not affected significantly by any extract, at a dose of mg kg-1 p.

The aqueous decoction increased pentobarbital-induced sleeping time, at doses of and mg kg-1 i. The ethanolic macerate inhibited contractions induced by acetylcholine, histamine, noradrenaline and barium chloride in four different smooth muscle tissues. The antispasmodic and anti-inflammatory activities were reproduced with quercetin, luteolin and quercetin 3-methyl ether, flavonoids that have been isolated from this plant.

A partial evaluation of the toxicity of the extracts was also performed. The pharmacological effects assayed are discussed in relation to the chemical constituents of this plant and its popular use in gastrointestinal disturbances, and inflammatory conditions could be related to the presence of the flavonoids. This site needs JavaScript to work properly.

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De Souza KC, et al. Epub Nov PMID: From ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesics and antispasmodics. Tits M, et al. J Ethnopharmacol. Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides Lam. Sabini MC, et al. Food Chem Toxicol. Epub Aug Ethnopharmacologic investigation of ginger Zingiber officinale.

Mascolo N, et al. Show more similar articles See all similar articles. Moresco KS, et al. Evid Based Complement Alternat Med. Epub Oct Barioni ED, et al. Epub Feb Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs. Ibulubo MT, et al. Pharmacognosy Res. Database survey of anti-inflammatory plants in South America: a review.

Int J Mol Sci. Epub Apr Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. MeSH terms Analgesics Actions. Animals Actions. Guinea Pigs Actions. Hypnotics and Sedatives Actions. In Vitro Techniques Actions. Lethal Dose 50 Actions. Male Actions. Mice Actions. Parasympatholytics Actions. Rats Actions. Rats, Inbred Strains Actions.

Substances Analgesics Actions. Plant Extracts Actions. Pentobarbital Actions. Full-text links [x] Elsevier Science.

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Achyrocline satureioides

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information on why. Click on one of the product search links in the left margin of this page to find other available products. You can also see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants in general. Macela has been the subject of western research and many of its long-time uses in herbal medicine have been validated by scientists. For more information about macela Achyrocline satureoides , please refer to the Database File for Macela in the Tropical Plant Database.


Pharmacological Investigations on Achyrocline Satureioides (LAM.) DC., Compositae

Achyrocline satureioides Lam. Naturally, its propagation structure constitutes the achenes, but propagation by apical cuttings is also feasible. The crude drug Achyroclines flos consists of its dried flowers, with golden yellow coloring and that presents aromatic and pleasant odor and slightly bitter taste, due to the presence of substances such as essential oils and flavonoids. Its flowers should be collected when fully developed, usually during autumn. In the Brazilian folk medicine, its tea is used as digestive, eupeptic, emmenagogue, antispasmodic, anti-inflammatory, expectorant and antidiarrheal. It is popular in treating disorders of the gastrointestinal tract and its anti-inflammatory action has been confirmed in pharmacological studies. Tests performed with isolated flavonoids quercetin, quercetin 3-methyl ether and luteolin of this species demonstrate that these compounds may be at least partially responsible for these activities.


Achyrocline satureioides (Lam.) DC.




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