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Phenylhydrazine PHZ , a potent chemical causes toxicity on various tissues at various levels. Administration of phenylhydrazine mainly causes haematotoxicity which leads to the haemolytic anemia. In mammals PHZ induced anemia increased In mammals PHZ induced anemia increased the iron absorption in spleen, liver and duodenum and finally iron metabolism was altered.
Local demand and supply of Fe would increase erythropoeitic activity of the spleen so the size of spleen was increased that create the splenomegaly. PHZ induced anemia activate immune response which triggers phagocytosis in the spleen and liver. Inhibition of gene expression with double strand RNA interference in Entamoeba histolytica. Mutations in both alleles of any of three genes for component Mutations in both alleles of any of three genes for component proteins result in the clinical phenotype.
The maternal mutation, an A to T transversion at nucleotide in the coding sequence, potentiates an asparagine to tyrosine change at position NY. Both mutant proteins could be synthesized, imported into mitochondria, and processed in vitro. Alignment comparisons with other thiamin pyrophosphate-requiring enzymes suggests the NY substitution could interfere with interactions of the protein with the cofactor causing inactivity.
Related Topics. Biochemistry and molecular biology,Proteomics and cancer. Follow Following. Membrane biochemistry. Molecular Biology. Nutritional Biochemistry. Biotechnology and Biochemical Engineering. Biochemistry and Biotechnology. Biochemistry and Bioinformatics. Ads help cover our server costs.
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Biochemistry, Molecular Biology