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Blood ; Supplement 1 : Objective There are many kinds of prognostic scoring systems of myelodysplastic syndrome MDS which are all risk-based stratification systems with their own dominance. So we do this research to explore the significance among this three systems in predicting the prognosis of MDS and to guide the clinical accurate prognosis stratification for personal treatment.
Then we compare the fatality rate of different stratifications in each system from the 0th month to the 60th month and contrast the 2-year fatality rate of each stratification. Results The difference of median survival time between different groups of prognostic scoring system was statistically significant. At the same time, we find that TP53 gene do strongly relate with complex karyotype at an odds of Integrated using 3 scoring system and taking the condition of gene mutations in clinical work is more favorable for clinical prognosis evaluation of MDS.
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[International prostate symptom score: comparison of doctor and patient].
Approximately one-third of patients with myelodysplastic syndrome MDS receiving allogeneic hematopoietic stem cell transplantation HSCT are cured by this treatment. Treatment failure may be due to transplant complications or relapse. Univariate and multivariate survival analyses were performed using Cox proportional hazards regression. High-risk category, as defined by the revised International Prognostic Scoring System IPSS-R , and monosomal karyotype were independently associated with relapse and lower overall survival after transplantation. On the other hand, older recipient age and high hematopoietic cell transplantation-comorbidity index HCT-CI were independent predictors of nonrelapse mortality.