Metrics details. Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium , also a medicinal plant, is used as a natural anti-inflammatory. Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. Aspidosperma pyrifolium activity was evaluated against Plasmodium falciparum using extracts in vitro.
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Background: Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory.
Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. Methods: Aspidosperma pyrifolium activity was evaluated against Plasmodium falciparum using extracts in vitro. Toxicity towards human hepatoma cells, monkey kidney cells or human monocytes freshly isolated from peripheral blood was also assessed. Anti-malarial activity of selected extracts and fractions that presented in vitro activity were tested in mice with a Plasmodium berghei blood-induced infection.
Results: The crude stem bark extract and the alkaloid-rich and ethyl acetate fractions from stem extract showed in vitro activity. None of the crude extracts or fractions was cytotoxic to normal monkey kidney and to a human hepatoma cell lines, or human peripheral blood mononuclear cells; the MDL 50 values of all the crude bark extracts and fractions were similar or better when tested on normal cells, with the exception of organic and alkaloidic-rich fractions from stem extract.
Two extracts and two fractions tested in vivo caused a significant reduction of P. Conclusion: Considering the high therapeutic index of the alkaloidic-rich fraction from stem extract of A. In its UPLC-HRMS analysis this fraction was shown to have two major components compatible with the bisindole alkaloid Leucoridine B, and a novel compound, which is likely to be responsible for the activity against malaria parasites demonstrated in in vitro tests.
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Full-text links Cite Favorites. Abstract Background: Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Figures Fig. Aspidosperma pyrifolium , a medicinal plant used as anti-inflammatory, known as pereiro in Brazil. A adult tree; B parts used for classification. Fractionation workflow of the plant stem bark a , and stem b extracts from Aspidosperma pyrifolium. The in vitro activity against P.
Putative fragmentation of the molecular ion for the proposed compound B Leucoridine E. The methoxy and acetyl group positions are not defined. See this image and copyright information in PMC.
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Xu YJ, et al. Mini Rev Med Chem. Show more similar articles See all similar articles. References WHO. Global Malaria Programme, Status report: artemisinin and artemisinin-based combination therapy resistance. Geneva: World Health Organization; Accessed 2 Apr Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. Emerging Plasmodium vivax resistance to chloroquine in South America: an overview.
Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon. Antimicrob Agents Chemother.
MeSH terms Animals Actions. Brazil Actions. Cells, Cultured Actions. Disease Models, Animal Actions. Female Actions. Haplorhini Actions. Humans Actions.
Mice Actions. Parasite Load Actions. Parasitemia Actions. Treatment Outcome Actions. Substances Antimalarials Actions. Plant Extracts Actions. Copy Download.
Dried Botanical ID