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Herbal plants with antioxidant activities are widely used in Ayurvedic medicine for cardiac and other problems. Arjunolic acid is one such novel phytomedicine with multifunctional therapeutic applications. It is a triterpenoid saponin, isolated earlier from Terminalia arjuna and later from Combretum nelsonii, Leandra chaeton etc. Arjunolic acid is a potent antioxidant and free radical scavenger.

The scientific basis for the use of arjunolic acid as cardiotonic in Ayurvedic medicine is proven by its vibrant functions such as prevention of myocardial necrosis, platelet aggregation and coagulation and lowering of blood pressure, heart rate and cholesterol levels. Its antioxidant property combined with metal chelating property protects organs from metal and drug induced toxicity.

It also plays an effective role in exerting protection against both type I and type II diabetes and also ameliorates diabetic renal dysfunctions. Its therapeutic multifunctionality is shown by its wound healing, antimutagenic and antimicrobial activity. The mechanism of cytoprotection conferred by arjunolic acid can be explained by its property to reduce the oxidative stress by enhancing the antioxidant levels.

Apart from its pathophysiological functions, it possesses dynamic insecticidal property and it is used as a structural molecular framework in supramolecular chemistry and nanoscience. Esters of ajunolic acid function as gelators of a wide variety of organic liquids.

Though the beneficial role of this triterpenoid has been assessed from various angles, a comprehensive review of its effects on biochemistry and organ pathophysiology is lacking and this forms the rationale of this review. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Cite Favorites. Abstract Herbal plants with antioxidant activities are widely used in Ayurvedic medicine for cardiac and other problems. Similar articles Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. Ghosh J, Sil PC. Ghosh J, et al. Epub Feb PMID: Review. Free Radic Biol Med. Epub Dec 4. PMID: Arjunolic acid: beneficial role in type 1 diabetes and its associated organ pathophysiology.

Manna P, Sil PC. Manna P, et al. Free Radic Res. Epub May 3. Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. Arch Toxicol. Epub Jan Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid. Epub Nov Show more similar articles See all similar articles. Manna S, et al. Melastomataceae in Rats. Djuichou Nguemnang SF, et al. Evid Based Complement Alternat Med. Xu J, et al.

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Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum Combretaceae leaf extracts. Makhafola TJ, et al. Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Review Actions. MeSH terms Animals Actions. Humans Actions. Molecular Structure Actions. Substances Anti-Inflammatory Agents Actions. Antineoplastic Agents Actions.

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Arjunolic Acid: A Novel Phytomedicine With Multifunctional Therapeutic Applications

A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. A molecular entity capable of donating a hydron to an acceptor Br o nsted base. Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. A substance or active part thereof that kills or slows the growth of bacteria. An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.


Arjunolic acid: A promising new building block for nanochemistry

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Showing metabocard for Arjunolic acid (HMDB0034502)

We'd like to understand how you use our websites in order to improve them. Register your interest. Arjunolic acid, the major extractable constituent of the heavy wood of Terminalia Arjuna , has the potential to be used as a rigid and functional molecular framework for the construction of nanosized supramolecular architectures and nanomaterials. The nanosized triterpenoid, arjunolic acid, showed efficient gelation of various organic solvents at low concentrations. The low molecular mass gelator molecules self-assembled in the solvents to form fibers of nanometer diameters. The movement of the solvent molecules was hindered inside the fibrous network leading to the formation of a gel. This is a preview of subscription content, log in to check access.

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