Unwanted side effects from a polluted water body may not be limited to the flora and fauna, they may also be transferred to the organisms along the food chain. Four water samples collected immediately and five days after rainfall from two locations inside the polluted Sungai Dua River SGD were tested for toxicity using the Allium cepa assay. The samples were analysed for metal content and were both macroscopically and microscopically evaluated. However, the inhibitory effects were not dose-dependent. No chromosomal aberration CA was induced at

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Sains Malaysiana 43 9 : — The identification of chromosomal aberrations in prostate cancer has been widely studied with several known oncogenes and tumor suppressor genes have successfully been discovered. The purpose of this study was to determine the chromosomal aberrations among Malaysian men of Southeast Asia population and discover those potential genes within that chromosomal aberrant region.

Thirty-six formalin-fixed paraffin embedded specimens consist of eight organ-confined prostate cancer cases, five with capsular invasion, 14 showed metastasis and nine cases had no tumor stage recorded, were analyzed by array CGH technique.

Chromosomal losses were frequently detected at 4q, 6q, 8p, 13q, 18q while gains at 7q, 11q, 12p, 16q and 17q. Gain of 16q Gains of 6q Several potential genes have also been found within that aberrant region which is myopodin 4qq27 , ROBO1 3pp The chromosomal aberrations identified by array CGH analysis could provide important clues to discover potential genes associated with prostate tumorigenesis of Malaysian men. Keywords: Array CGH ; chromosomal aberrations; prostate cancer; putative genes.

Pengenalpastian aberasi kromosom dalam kanser prostat telah dikaji secara meluas dengan beberapa onkogen dan gen penindas tumor telah berjaya ditemui. Tujuan kajian ini adalah untuk menentukan aberasi kromosom dalam kalangan lelaki Malaysia di Asia Tenggara dan seterusnya mengenal pasti gen berpotensi yang terkandung dalam kawasan kromosom yang mengalami aberasi. Sejumlah 36 blok tisu spesimen kanser prostat yang diawet formalin dan terbenam dalam lilin parafin, digunakan dalam kajian ini yang terdiri daripada 8 kes organ-terbatas kanser prostat, 5 kes dengan kapsular invasif, 14 kes menunjukkan metastasis manakala 9 kes tiada rekod peringkat tumor.

Sampel dianalisis oleh teknik penghibridan perbandingan genomik tatasusunan. Delesi kromosom lebih kerap dikesan pada 5q, 6q, 8p, 13q, 18q manakala amplifikasi pada 7q, 11q, 12p, 16q dan 17q. Amplifikasi 16q Amplifikasi 6q Beberapa gen yang berpotensi juga telah ditemui di dalam kawasan aberasi berkenaan termasuklah gen myopodin 4qS27 , ROBO1 3pp Aberasi kromosom yang dikesan oleh teknik tatasusunan CGH memberi petunjuk penting terhadap penemuan gen berpotensi yang berkemungkinan terlibat dalam tumorigenesis prostat pesakit Malaysia.

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