ABERASI KROMOSOM PDF

Unwanted side effects from a polluted water body may not be limited to the flora and fauna, they may also be transferred to the organisms along the food chain. Four water samples collected immediately and five days after rainfall from two locations inside the polluted Sungai Dua River SGD were tested for toxicity using the Allium cepa assay. The samples were analysed for metal content and were both macroscopically and microscopically evaluated. However, the inhibitory effects were not dose-dependent. No chromosomal aberration CA was induced at

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Sains Malaysiana 43 9 : — The identification of chromosomal aberrations in prostate cancer has been widely studied with several known oncogenes and tumor suppressor genes have successfully been discovered. The purpose of this study was to determine the chromosomal aberrations among Malaysian men of Southeast Asia population and discover those potential genes within that chromosomal aberrant region.

Thirty-six formalin-fixed paraffin embedded specimens consist of eight organ-confined prostate cancer cases, five with capsular invasion, 14 showed metastasis and nine cases had no tumor stage recorded, were analyzed by array CGH technique.

Chromosomal losses were frequently detected at 4q, 6q, 8p, 13q, 18q while gains at 7q, 11q, 12p, 16q and 17q. Gain of 16q Gains of 6q Several potential genes have also been found within that aberrant region which is myopodin 4qq27 , ROBO1 3pp The chromosomal aberrations identified by array CGH analysis could provide important clues to discover potential genes associated with prostate tumorigenesis of Malaysian men. Keywords: Array CGH ; chromosomal aberrations; prostate cancer; putative genes.

Pengenalpastian aberasi kromosom dalam kanser prostat telah dikaji secara meluas dengan beberapa onkogen dan gen penindas tumor telah berjaya ditemui. Tujuan kajian ini adalah untuk menentukan aberasi kromosom dalam kalangan lelaki Malaysia di Asia Tenggara dan seterusnya mengenal pasti gen berpotensi yang terkandung dalam kawasan kromosom yang mengalami aberasi. Sejumlah 36 blok tisu spesimen kanser prostat yang diawet formalin dan terbenam dalam lilin parafin, digunakan dalam kajian ini yang terdiri daripada 8 kes organ-terbatas kanser prostat, 5 kes dengan kapsular invasif, 14 kes menunjukkan metastasis manakala 9 kes tiada rekod peringkat tumor.

Sampel dianalisis oleh teknik penghibridan perbandingan genomik tatasusunan. Delesi kromosom lebih kerap dikesan pada 5q, 6q, 8p, 13q, 18q manakala amplifikasi pada 7q, 11q, 12p, 16q dan 17q. Amplifikasi 16q Amplifikasi 6q Beberapa gen yang berpotensi juga telah ditemui di dalam kawasan aberasi berkenaan termasuklah gen myopodin 4qS27 , ROBO1 3pp Aberasi kromosom yang dikesan oleh teknik tatasusunan CGH memberi petunjuk penting terhadap penemuan gen berpotensi yang berkemungkinan terlibat dalam tumorigenesis prostat pesakit Malaysia.

Kata kunci: Aberasi kromosom; gen yang berkemungkinan; kanser prostat; tatasusunan CGH. Andrews, W. Slit-Robo interactions during cortical development. Journal of Anatomy Berhane, N. Mol Biol Rep. Brown, R. Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer.

Bubendorf, L. Survey of gene amplifications during prostate cancer progression by high-throughput fluorescence in situ hybridization on tissue microarrays. Cancer Research 59 4 : Diamandis, E. Clinical applications of tumor suppressor genes and oncogenes in cancer. Clinica Chimica Acta 2 : Fearon, E. A genetic model for Colorectal Tumorigenesis. Cell Ferlay, J. Fu, W. Genetic changes in clinically organ-confined prostate cancer by comparative genomic hybridization. Urolog y 56 5 : Gelmann, E.

Prostate molecular oncogenesis: Gene deletions and somatic mutations. USA: Humana Press. Hashida, H. Clinical significance of transmembrane 4 superfamily in colon cancer. British Journal of Cancer 89 1 : Hooker, S. Prostate Cancer Prostatic Dis.

Jing, L. Expression of myopodin induces suppression of tumor growth and metastasis. Kasahara, K. Detection of genetic alterations in advanced prostate cancer by comparative genomic hybridization. Cancer Genet Cytogenet. Kiyohara, C. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis.

Latil, A. Quantification of expression of netrins, slits and their receptors in human prostate tumors. Lengauer, C. Genetic instabilities in human cancers. Nature Lerman, M. The kb lung cancer homozygous deletion region on human chromosome 3p The International Lung Cancer Chromosome 3p Cancer Res.

Lin, F. Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Ma, S. Increased SLIT immunoreactivity as a biomarker for recurrence in endometrial carcinoma.

American Journal of Obstetrics and Gynecology 68ee Mhawech, P. Cancer Paris, P. Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors. Hum Mol Genet.

Ribeiro, F. Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic inbalances in primary prostate carcinomas. Cancer 5: Ross, J. Sanchez-Carbayo, M. Tumor suppressor role for myopodin in bladder cancer: Loss of nuclear expression of myopodin is cellcycle dependent and predicts clinical outcome. Oncogene Sanyal, S. Polymorphisms in DNA repair and metabolic genes in bladder cancer.

Carcinogenesis Genetic aberrations in prostate cancer by microarray analysis. Cancer 6 : Sho, M. Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer. International Journal of Cancer Solinas-Toldo, S. Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances. Genes Chromosome Cancer Cancer 94 2 : Evaluation of genetic patterns in different tumor areas of intermediate-grade prostatic adenocarcinomas by high-resolution genomic array analysis.

Genes Chromosomes Cancer 39 3 : Visakorpi, T. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Weins, A. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.

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